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Predictive Value of Uric Acid/Albumin Ratio for Postoperative Atrial Fibrillation Following Isolated Coronary Artery
Ilhan Koyuncu1, Saadet Aydın, Ecem Gurses1
1University of Bakircay Medical School Cardiology Department Izmir Izmir Turkey Cardiology Department, University of Bakircay Medical School, Izmir, Izmir, Turkey.
Insights
The uric acid/albumin ratio (UAR) predicts postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG). Higher UAR indicates an increased risk of developing POAF, aiding in patient risk stratification.
Area of Science:
- Cardiology
- Biochemistry
- Medical Diagnostics
Background:
- Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, increasing patient morbidity and mortality.
- Identifying reliable predictors for POAF is crucial for improving patient outcomes following coronary artery bypass grafting (CABG).
Purpose of the Study:
- To evaluate the predictive value of the uric acid/albumin ratio (UAR) for the occurrence of POAF in patients undergoing isolated CABG.
- To determine if UAR serves as an independent risk factor for POAF.
Main Methods:
- A retrospective analysis of 396 patients who underwent isolated CABG between June 2017 and January 2024.
- Uric acid/albumin ratio (UAR) was calculated using serum uric acid and albumin levels.
- Statistical analyses, including univariate, multivariate regression, and ROC analysis, were performed to assess risk factors and predictive performance.
Main Results:
- Patients who developed POAF (n=75) were older than those who did not (n=321).
- Independent risk factors for POAF included age, C-reactive protein, hypertension, serum uric acid, and UAR.
- UAR demonstrated superior predictive performance (AUC: 0.775) compared to uric acid (AUC: 0.649) and albumin (AUC: 0.606) for POAF.
Conclusions:
- The uric acid/albumin ratio (UAR) is an independent risk factor for postoperative atrial fibrillation following isolated CABG.
- UAR shows significant potential as a predictive biomarker for POAF in this patient population.
Introduction:
Postoperative atrial fibrillation (POAF) is associated with an increased risk of morbidity and mortality. This study aims to investigate the predictive value of uric acid/albumin ratio (UAR) for POAF following isolated coronary artery bypass grafting (CABG).
Methods:
This retrospective study screened patients who underwent isolated CABG between June 2017 and January 2024. POAF was diagnosed using standard clinical criteria. UAR was calculated by dividing the uric acid level by the albumin value.
Results:
This study included a total of 396 patients, who were categorized into two groups: POAF- and POAF+. Among them, 321 patients (mean age: 61.7 ± 10.8 years; 74.7% male) belonged to the POAF- group, while 75 patients (mean age: 71.3 ± 10.04 years; 68.1% male) were in the POAF+ group. While there were no significant differences observed between the groups in terms of sex, those in the POAF+ group were statistically older. The univariate and multivariate regression analyses revealed that age, C-reactive protein, hypertension, serum uric acid level, and UAR are independent risk factors for POAF. In the receiver operating characteristics analysis, the UAR (area under the curve [AUC]: 0.775) was found to be a better indicator compared to uric acid (AUC: 0.649) and serum albumin (AUC: 0.606), with a sensitivity of 70.5% and a specificity of 69.2%.
Conclusion:
UAR was shown to be an independent risk factor for POAF following isolated CABG.
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