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Related Concept Videos

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Tactile and Chemical Senses01:27

Tactile and Chemical Senses

Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex. This...

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Related Experiment Video

Updated: Jun 9, 2026

Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

Response to Doty 2025, predicting odor from structure is useful.

Robert Pellegrino1,2, Emily J Mayhew3, Joel D Mainland1,4

  • 1Monell Chemical Senses Center, Philadelphia, PA 19104, United States.

Chemical Senses
|February 18, 2026
PubMed
Summary

This study highlights advances in quantifying odor space, challenging historical views. Recent progress in physicochemical modeling offers predictive rules for olfaction, surpassing previous limitations.

Area of Science:

  • Olfactory science
  • Chemosensation research
  • Sensory perception

Background:

  • Historical odor classification reviews often overlook modern advancements.
Keywords:
chemosensory perceptionhistorymachine learningodor mixturespsychophysicsstructure–odor relationships

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  • Odor perception is influenced by cognitive factors, complicating direct mapping to chemical properties.
  • Previous models struggled to predict odor qualities based solely on molecular structure.