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Unveiling the epigenetic landscape of AMPK regulation in cancer metabolism

Shweta Dongre1, Arunima Jaiswal1, Megha Chaudhary1

  • 1Department of Biochemistry, Central University of Rajasthan, India.

Gene
|February 18, 2026
PubMed

Insights

Cancer cells reprogram metabolism via epigenetic changes affecting AMP-activated protein kinase (AMPK). Understanding AMPK

Area of Science:

  • Oncology and Molecular Biology
  • Cancer Metabolism Research
  • Epigenetics and Gene Regulation

Background:

  • Cancer cells exhibit metabolic reprogramming through genetic mutations and epigenetic modifications.
  • AMP-activated protein kinase (AMPK) is a critical regulator of cellular energy homeostasis and plays a significant role in cancer metabolism.
  • Epigenetic mechanisms, including DNA methylation, histone remodeling, and non-coding RNAs, are increasingly recognized as regulators of AMPK.

Purpose of the Study:

  • To provide a comprehensive overview of the epigenetic regulation of AMPK in cancer.
  • To highlight the role of epigenetic modifications in AMPK-mediated metabolic reprogramming.
  • To explore the potential of targeting AMPK epigenetic regulation in precision oncology.

Main Methods:

  • Review of existing literature on AMPK function and epigenetic regulation in cancer.
  • Analysis of the interplay between non-coding RNAs, DNA methylation, histone modifications, and AMPK signaling.
  • Discussion of the implications of AMPK epigenetic regulation in cancer metabolism.

Main Results:

  • Emerging evidence indicates that AMPK is tightly controlled by epigenetic mechanisms affecting its gene expression, activation, and stability.
  • Non-coding RNAs, DNA methylation, and histone modifications dynamically regulate AMPK signaling pathways.
  • Epigenetic signatures governing AMPK regulation are being investigated as potential therapeutic targets.

Conclusions:

  • Epigenetic regulation of AMPK is a crucial, yet underexplored, aspect of cancer metabolic reprogramming.
  • Targeting the epigenetic control of AMPK offers promising avenues for precision oncology strategies.
  • Further research into AMPK epigenetic mechanisms is essential for developing novel cancer therapies.
Keywords:
AMPKCancercircRNAlncRNAmiRNAncRNA

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