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Prevention of Stillbirth
Robert M Silver1, Uma M Reddy2
1Department of Obstetrics and Gynecology, University of Utah, 30 North 1900 East, Helix Building 5th Floor, Salt Lake City, UT 84132, USA.
Clinics in Perinatology
|February 18, 2026
Summary
Stillbirth prevention needs better screening for placental insufficiency, the main cause. Interventions like low-dose aspirin and managing maternal health are key, alongside education and prevention bundles.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Perinatal Health
Background:
- Placental insufficiency is the primary driver of stillbirth in high-resource settings.
- Conventional risk factors (e.g., maternal age, BMI) offer limited predictive accuracy.
- Advanced screening methods are crucial for effective stillbirth prevention.
Purpose of the Study:
- To review current strategies for stillbirth prevention.
- To highlight the importance of identifying and managing placental insufficiency.
- To explore effective interventions and future research directions.
Main Methods:
- Literature review of placental insufficiency and stillbirth prevention strategies.
- Analysis of traditional versus advanced risk factor assessment.
- Evaluation of pharmacological and non-pharmacological interventions.
Main Results:
- Ultrasound, Doppler studies, and biomarkers show potential for universal screening.
- Low-dose aspirin effectively reduces placental-related complications.
- Maternal condition management (hypertension, diabetes), fetal movement awareness, and prevention bundles show promise.
Conclusions:
- A multifaceted approach is essential for stillbirth prevention.
- Enhanced screening and targeted interventions are needed to reduce stillbirth rates.
- Further research should focus on refining risk stratification and delivery timing.
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