Related Experiment Video
Updated: Feb 20, 2026
09:17
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
878
Curcumin-loaded copper/iron bimetallic nanoparticle-incorporated hydrogel scaffold: a sequential microenvironment
Fengyang Hu1, Lei Ji2, Haixia Chen1
1Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials, Institute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China.
Journal of Nanobiotechnology
|February 19, 2026
Summary
This study presents a novel hydrogel scaffold for diabetic wound healing. The scaffold effectively reduces inflammation, clears reactive oxygen species, and promotes tissue regeneration for improved chronic wound repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Diabetic wound management is challenging due to poor tissue microenvironments.
- Excessive reactive oxygen species (ROS), inflammation, and infection impede healing.
Purpose of the Study:
- To develop a hybrid hydrogel scaffold for infected chronic wound healing.
- To sequentially reprogram the wound microenvironment for enhanced regeneration.
Main Methods:
- Microfluidic 3D printing technique used to create the hybrid hydrogel scaffold (SF@NP-Cur).
- Scaffold incorporates curcumin-loaded copper/iron bimetallic nanoparticles (NP-Cur).
Main Results:
- The scaffold scavenges ROS via oxidase/peroxidase-like activities.
- Multimodal antibacterial effects achieved through copper release and photothermal properties.
- Promotes fibroblast migration, collagen deposition, and angiogenesis.
- Facilitates M1 to M2 macrophage polarization for a pro-regenerative phenotype.
- Successfully accelerates diabetic wound reconstruction by reducing ROS and inflammation, increasing M2 macrophages, and enhancing neovascularization.
Conclusions:
- The immunomodulatory hydrogel scaffold is a promising therapeutic strategy for chronic wound repair.
- Reprograms the wound microenvironment for impaired tissue reconstruction.
