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Sequence-Defined Oligourethane Isomeric Mixtures for Irreversible Encryption.

Lingxiao Guo1, Qiangqiang Shi1, Jin Zhang1

  • 1State Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, China.

Angewandte Chemie (International Ed. in English)
|February 19, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces isomeric mixtures of sequence-defined oligourethanes (SDOs) for secure molecular data encryption. These mixtures create irreversible encryption, offering a novel approach to data security and anti-counterfeiting.

Keywords:
MALDI‐TOF MS/MSirreversible encryptionisomeric mixturesequence decodingsequence‐defined oligourethane

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Area of Science:

  • Polymer Chemistry
  • Molecular Cryptography
  • Information Security

Background:

  • Sequence-defined polymers (SDPs) are explored for data storage and encryption.
  • Current methods rely on complex synthesis (e.g., longer chains, diverse monomers).
  • Need for simpler, more secure molecular encryption strategies.

Purpose of the Study:

  • Introduce a novel encryption mechanism using isomeric mixtures of sequence-defined oligourethanes (SDOs).
  • Demonstrate an intrinsically one-way, irreversible molecular encryption process.
  • Develop a scalable platform for next-generation data security and anti-counterfeiting.

Main Methods:

  • Utilized isomeric mixtures of sequence-defined oligourethanes (SDOs).
  • Employed MALDI-TOF MS to demonstrate concealed compositional identity due to identical molecular weights.
  • Applied tandem MS/MS fragmentation to generate degenerate decoding paths.
  • Integrated mixtures into CMYK molecular digital inks for printing and transmission.

Main Results:

  • Isomeric SDO mixtures collapse into a single peak in MALDI-TOF MS, hiding composition.
  • Tandem MS fragmentation produces multiple, non-unique decoding pathways, preventing reconstruction.
  • Proof-of-concept with four octameric isomers demonstrated the encryption principle.
  • Successful integration into CMYK inks for secure information transmission.

Conclusions:

  • Isomeric oligomer mixtures represent a new class of molecular cryptographic media.
  • The method offers intrinsically one-way, irreversible molecular encryption.
  • This approach bridges chemical design with information theory for advanced data security.