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The Impact of Cold Application on Pain Reduction in Adult Patients Receiving Intramuscular Injections: A Systematic
Hanife Durgun1, Fatma Aksoy Şirin1, Berna Köktürk Dalcalı2
1Department of Fundamentals of Nursing, Ordu University Faculty of Health Sciences, Ordu, Türkiye.
Florence Nightingale Journal of Nursing
|February 19, 2026
Summary
Cold application effectively reduces pain for adults receiving intramuscular injections. This systematic review confirms cold therapy as a beneficial nursing intervention for pain management in this patient group.
Area of Science:
- Nursing interventions
- Pain management
- Evidence-based practice
Background:
- Intramuscular injections are a common medical procedure associated with localized pain.
- Effective pain reduction strategies are crucial for patient comfort and adherence to treatment.
- The role of non-pharmacological interventions like cold application warrants systematic investigation.
Purpose of the Study:
- To systematically review existing literature on the efficacy of cold application for reducing pain.
- To assess the impact of cold therapy in adult patients undergoing intramuscular injections.
- To provide evidence-based recommendations for nursing practice.
Main Methods:
- Systematic review of 216 studies published between 2014 and 2024.
- Literature search conducted across major databases (PubMed, Web of Science, Scopus, etc.).
- Nine studies (5 RCTs, 4 quasi-experimental) meeting inclusion criteria were analyzed following PRISMA guidelines.
Main Results:
- Nine studies involving adult patients (18-60 years) met the inclusion criteria.
- Cold application methods included cold spray (5 studies) and cold/ice application (4 studies).
- Cold application demonstrated effectiveness in reducing pain associated with intramuscular injections.
Conclusions:
- Cold application is an effective nursing intervention for mitigating pain from intramuscular injections.
- The findings support the use of cold therapy as a non-pharmacological pain management strategy.
- Further high-quality, large-scale research is recommended to reinforce these conclusions.

