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Updated: May 6, 2026

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Post-Botulinum Headache in Cosmetic Practice: A Prospective Study.

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  • 1Private Dermatology Practice, Ankara, Türkiye.

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Post-botulinum headache is a rare side effect, affecting 12.7% of patients, primarily first-time users receiving upper facial injections. This headache is typically mild, short-lived, and resolves on its own.

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Area of Science:

  • Neurology
  • Dermatology
  • Aesthetic Medicine

Background:

  • Botulinum toxin injections are common for cosmetic and functional uses, generally considered safe.
  • Headache is a known but understudied adverse effect following botulinum toxin procedures, especially in cosmetic applications.

Purpose of the Study:

  • To determine the incidence and characteristics of headaches after botulinum toxin injections.
  • To identify potential risk factors for post-injection headaches in different anatomical areas.

Main Methods:

  • A prospective observational study involved 102 adult patients receiving abobotulinumtoxinA injections in facial, masseter, or axillary areas.
  • Headache occurrence was monitored via phone and follow-up visits within one month.
  • Data collected included patient demographics, prior botulinum toxin use, injection pain, toxin dose, and headache details.

Main Results:

  • Post-botulinum headache occurred in 12.7% of patients, characterized as mild-to-moderate and transient.
  • Headaches were significantly more common in first-time botulinum toxin users (45.5%) versus those previously treated (8.8%).
  • Headaches were only observed after upper facial injections; no headaches occurred with exclusive masseter or axillary treatments.

Conclusions:

  • Headache following botulinum toxin is infrequent, benign, and temporary.
  • First-time patients receiving upper facial injections are most susceptible.
  • Findings assist clinicians in patient counseling regarding potential side effects and managing expectations.