Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

2.2K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of systemic isotretinoin and doxycycline therapy on hematological parameters patients with acne vulgaris.

Cutaneous and ocular toxicology·2026
Same author

Immunohistochemical investigation of transferrin receptor 2 (TFR2) immunoreactivity in patients with psoriasis vulgaris.

Cutaneous and ocular toxicology·2026
Same author

Optimizing Intraoperative Hemostasis in Hair Transplantation: A Follicle-Based Tumescent Infiltration Approach.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Evaluation of Depression, Anxiety, and Sleep Quality in Patients With Acne Vulgaris Receiving Isotretinoin Treatment.

Human psychopharmacology·2026
Same author

Post-Botulinum Headache in Cosmetic Practice: A Prospective Study.

Journal of cosmetic dermatology·2026
Same author

Immunohistochemical evaluation of acyl-CoA synthetase long-chain family member 4 (ACSL4) immunoreactivity in malignant melanoma specimens.

Histochemistry and cell biology·2026

Related Experiment Video

Updated: May 7, 2026

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
03:22

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

14.9K

Is Local Tranexamic Acid Worth Using in Hair Transplantation? An Intrapatient Comparison.

Ümit Akpınar1, Mehmet Semih Çelik2

  • 1Private Dermatology Practice, Ankara, Turkey. drumitakpinar@gmail.com.

Aesthetic Plastic Surgery
|May 6, 2026
PubMed
Summary

Adrenaline-based tumescent solutions showed better bleeding control during hair transplantation donor area harvesting than those including tranexamic acid (TXA). Further research is needed to determine TXA's independent contribution to hemostasis.

Keywords:
BleedingHair transplantationHarvestingTranexamic acid

More Related Videos

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

2.1K
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

20.9K

Related Experiment Videos

Last Updated: May 7, 2026

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
03:22

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

14.9K
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

2.1K
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

20.9K

Area of Science:

  • Hair transplantation surgery
  • Dermatologic surgery
  • Surgical hemostasis

Background:

  • Excessive bleeding during hair transplantation donor site harvesting can compromise surgical control and graft quality.
  • Standard tumescent solutions utilize adrenaline, but the added benefit of local tranexamic acid (TXA) is not well-established.

Purpose of the Study:

  • To assess if local tranexamic acid (TXA) offers additional hemostatic benefits over standard adrenaline-based tumescent solutions during follicular unit excision (FUE) donor area harvesting.

Main Methods:

  • An intrapatient-controlled, single-blinded study involving 57 male patients undergoing FUE.
  • Two adjacent 4 cm² donor areas per patient were infiltrated with either adrenaline-only or adrenaline plus TXA (50 mg/mL) tumescent solution.
  • Bleeding was evaluated using a 10-point visual scale immediately after harvesting approximately 20 grafts per area.

Main Results:

  • Adrenaline-only tumescent areas exhibited significantly lower intraoperative bleeding scores compared to TXA-treated areas (median [IQR] 2 [2-3] vs. 3 [2-4]; p < 0.001).
  • A large effect size (r = 0.56) indicated a substantial difference in bleeding control.

Conclusions:

  • Under the study's protocol, adrenaline-based tumescence provided superior immediate intraoperative hemostasis in the donor area.
  • The independent effect of tranexamic acid could not be definitively determined due to variations in total adrenaline exposure between the groups.