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Association Between Fetal Nuchal Translucency Measurements and Pregnancy Outcomes
Xiang-Na Zhao1, Jing Chang2, Hao-Gang Sun1
1First Affiliated Hospital, Shihezi University, Shihezi, 832008, People's Republic of China.
International Journal of Women'S Health
|February 19, 2026
Summary
The optimal fetal nuchal translucency (NT) cutoff is 2.5mm in Shihezi. NT thickening predicts abnormalities and adverse outcomes, but should be assessed with maternal factors.
Area of Science:
- Obstetrics and Gynecology
- Prenatal Diagnosis
- Fetal Medicine
Background:
- Nuchal translucency (NT) screening is a key component of first-trimester prenatal diagnosis.
- Identifying optimal NT cutoff values is crucial for accurate risk assessment in specific populations.
- Understanding the association between NT and various adverse pregnancy outcomes is essential for clinical management.
Purpose of the Study:
- To determine the optimal cutoff value for fetal nuchal translucency (NT) in the Shihezi region.
- To analyze the predictive value of NT and other high-risk factors for adverse pregnancy outcomes.
- To investigate the correlation between NT thickening and specific fetal and maternal complications.
Main Methods:
- Retrospective analysis of pregnant women undergoing NT screening between January 2021 and December 2023.
- Calculation of the optimal NT cutoff value for predicting pregnancy outcomes.
- Statistical analysis of associations between NT measurements, maternal factors, and pregnancy outcomes.
Main Results:
- An NT cutoff of 2.5mm was identified as optimal for NT thickening in the Shihezi area.
- NT thickening (≥2.0mm) showed significant association with structural abnormalities (P<0.001), chromosomal abnormalities (P=0.008), and adverse outcomes (P<0.001).
- Increased NT thickness correlated with higher risks of adverse outcomes (OR=13.090 for NT≥3.5mm) and specific conditions like macrosomia, preterm birth, and miscarriage.
Conclusions:
- NT=2.5mm serves as the cutoff for NT thickening in the Shihezi region.
- NT thickening is linked to structural and chromosomal abnormalities, and miscarriage.
- NT, advanced maternal age (≥35), and hypertensive disorders of pregnancy (HDP) are independent risk factors, necessitating combined assessment with prenatal screening and maternal factors.
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