Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

5.0K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
5.0K
Inhaled Medications01:23

Inhaled Medications

868
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
868
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

868
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
868
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

577
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
577
Drug Delivery: Overview01:16

Drug Delivery: Overview

952
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
952
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

1.3K
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissociative depression is associated with higher levels of disability than non-dissociative depression: An international multi-site study.

Journal of affective disorders·2026
Same author

The relationship between complex PTSD and dissociation: longitudinal findings across Western and South Asian female samples.

Social psychiatry and psychiatric epidemiology·2026
Same author

Serotonin and neurofilament light chain in alcohol-related suicide: Preliminary case observations.

Brain, behavior, & immunity - health·2025
Same author

Biotechnology and the Future of Vaccines-From Novel Routes and Vectors to Safety, Efficacy, and Global Impact.

Vaccines·2025
Same author

Infection and Prevention of Rabies Viruses.

Microorganisms·2025
Same author

Novel Administration Routes, Delivery Vectors, and Application of Vaccines Based on Biotechnologies: A Review.

Vaccines·2024

Related Experiment Video

Updated: Feb 20, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

41.6K

Inhalation: A Smart Strategy and Increasing Potential for Drug Delivery.

Shao-Cheng Wang1,2, Tsu-Hsiang Kuo3, Chung-I Rai4

  • 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 833, Taiwan.

Drug Design, Development and Therapy
|February 19, 2026
PubMed
Summary
This summary is machine-generated.

Inhaled drug delivery offers rapid, localized treatment with fewer side effects than other methods. Advances in inhaler technology and new applications like vaccines are expanding its use in precision medicine.

Keywords:
administration routedrug deliveryinhalation deviceinhaled drug

More Related Videos

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
15:04

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

11.4K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.5K

Related Experiment Videos

Last Updated: Feb 20, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

41.6K
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
15:04

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

11.4K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.5K

Area of Science:

  • Pharmaceutical Sciences
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Inhaled drug delivery provides advantages over oral, intravenous, or transdermal routes, including rapid onset and reduced systemic side effects.
  • Traditionally used for respiratory diseases like asthma and COPD, inhalation therapy is now expanding into systemic treatments, vaccines, and biologics.

Purpose of the Study:

  • To review the advancements and evolving landscape of inhaled drug delivery.
  • To highlight innovative devices, emerging trends, and future directions in inhalation therapy.

Main Methods:

  • Review of current literature on inhalation drug delivery technologies and applications.
  • Analysis of emerging trends, including smart inhalers, nanoparticles, and gene/RNA therapies.

Main Results:

  • Technological innovations in devices (dry powder, soft mist, smart inhalers) enhance precision dosing and adherence monitoring.
  • Emerging applications include systemic therapies, vaccines, and biologics, expanding the scope beyond pulmonary diseases.
  • Challenges persist in formulation stability, device compatibility, and environmental impact.

Conclusions:

  • Inhalation therapy is a key component of precision and patient-centric medicine, offering new treatment and prevention avenues.
  • Future research should focus on green technologies, telehealth integration, and personalized inhaler selection for broader therapeutic applications.