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Updated: May 12, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

EPPT-CTG regeneration using rhFGF-2/CO₃Ap for Cemental Tear Defects: A case report.

Takayoshi Nagahara^1,2, Tomoyuki Iwata², Keinoshin Wada³

¹Department of Dentistry, Nippon Kokan Fukuyama Hospital, Fukuyama, Japan.

Clinical Advances in Periodontics

|February 19, 2026

Summary

Regenerative therapy combining recombinant human fibroblast growth factor-2 (rhFGF-2), carbonate apatite (CO3Ap), and connective tissue graft (CTG) via the entire papilla preservation technique (EPPT) successfully treated a cemental tear-associated bone defect. This minimally invasive approach achieved significant bone fill and soft tissue regeneration in an elderly patient.

Area of Science:

Periodontal regenerative therapy
Minimally invasive surgical techniques
Biomaterials in dentistry

Keywords:

alveolar bone loss fibroblast growth factor 2 periodontal abscess periodontal regeneration

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Background:

Cemental tears are rare, challenging conditions often misdiagnosed as vertical root fractures or endodontic-periodontal lesions.
Predictable treatment protocols for cemental tears with non-contained bone defects are lacking.
Minimally invasive techniques like EPPT and CTG may enhance wound stability and outcomes when combined with biologic agents.