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EPPT-CTG regeneration using rhFGF-2/CO3Ap for Cemental Tear Defects: A case report
Takayoshi Nagahara1,2, Tomoyuki Iwata2, Keinoshin Wada3
1Department of Dentistry, Nippon Kokan Fukuyama Hospital, Fukuyama, Japan.
Clinical Advances in Periodontics
|February 19, 2026
Summary
Regenerative therapy combining recombinant human fibroblast growth factor-2 (rhFGF-2), carbonate apatite (CO3Ap), and connective tissue graft (CTG) via the entire papilla preservation technique (EPPT) successfully treated a cemental tear-associated bone defect. This minimally invasive approach achieved significant bone fill and soft tissue regeneration in an elderly patient.
Area of Science:
- Periodontal regenerative therapy
- Minimally invasive surgical techniques
- Biomaterials in dentistry
Background:
- Cemental tears are rare, challenging conditions often misdiagnosed as vertical root fractures or endodontic-periodontal lesions.
- Predictable treatment protocols for cemental tears with non-contained bone defects are lacking.
- Minimally invasive techniques like EPPT and CTG may enhance wound stability and outcomes when combined with biologic agents.
