Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

2.8K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
2.8K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

612
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
612
Inflammatory Response01:28

Inflammatory Response

17.3K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.3K
Inflammation01:38

Inflammation

62.6K
Overview
62.6K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.2K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.2K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

17.1K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
17.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative Music Therapy for Depression-related Disorders (iMTDep) - study protocol for a randomised controlled trial.

Trials·2026
Same author

Early career nurses' well-being at work in care settings for older people - a cross-sectional survey.

Contemporary nurse·2026
Same author

Overstaffing and Understaffing Are Associated With Adverse Events In a Level III Neonatal Intensive Care Unit.

Journal of patient safety·2026
Same author

Association between infant and toddler gut microbiota composition and later executive functioning.

Development and psychopathology·2026
Same author

Characterization of real-world clinical and pathological differences between HER2-0 and HER2-low localized breast cancer.

Cancer treatment and research communications·2026
Same author

Dexmedetomidine in oxycodone patient-controlled analgesia after lumbar spinal fusion: A randomized, double-blind, placebo-controlled trial.

Journal of clinical anesthesia·2026

Related Experiment Video

Updated: Feb 21, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.8K

Uncomplicated and Complicated Acute Appendicitis Induce Different Cytokine Patterns.

Tatu Han1,2, Tuomas Borman3, Sanja Vanhatalo2,4,5

  • 1Department of Surgery, University of Turku, Turku, Finland.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|February 19, 2026
PubMed
Summary

Complicated appendicitis shows distinct immune responses compared to uncomplicated cases. Interleukin-6 (IL-6) levels can help diagnose complicated appendicitis, offering insights into its immunopathology.

Keywords:
IL‐6 predictionappendicitisimmune responseinfection

More Related Videos

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.9K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

916

Related Experiment Videos

Last Updated: Feb 21, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.8K
Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.9K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

916

Area of Science:

  • Immunology
  • Gastroenterology
  • Surgical Pathology

Background:

  • Acute appendicitis is a common surgical emergency with unclear immunopathogenesis.
  • Distinguishing between uncomplicated and complicated appendicitis is crucial for patient management.

Purpose of the Study:

  • To analyze serum cytokine profiles in appendicitis patients.
  • To evaluate the diagnostic potential of cytokines in differentiating appendicitis severity.
  • To gain insights into the immunopathology of appendicitis.

Main Methods:

  • Prospective study analyzing serum samples from 113 patients.
  • Measured 48 cytokines using pre-defined subgroup analysis.
  • Compared cytokine levels between uncomplicated (72 patients) and complicated (41 patients) appendicitis groups.

Main Results:

  • Complicated appendicitis demonstrated significantly elevated levels of interleukin-6 (IL-6), hepatocyte growth factor (HGF), and monocyte chemoattractant protein 1 (MCP-1) compared to uncomplicated cases.
  • IL-6 exhibited the highest diagnostic performance (AUC 0.785) for predicting complicated appendicitis.
  • Distinct immune responses were observed between the two appendicitis classifications.

Conclusions:

  • The immune response differs significantly between complicated and uncomplicated appendicitis, suggesting they represent distinct disease entities.
  • Interleukin-6 (IL-6) shows potential as a diagnostic biomarker for complicated appendicitis.