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Endosialin (CD248) Cancer Role and Therapeutics: 33 Years on

Beverly A Teicher1, Li Chen2, Dianne L Newton3

  • 1Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.

Molecular Cancer Therapeutics
|February 19, 2026
PubMed

Insights

CD248 (endosialin) is a promising therapeutic target for sarcomas and fibrotic diseases due to its selective expression in tumors. Research explores its role in cancer therapy, particularly for Ewing

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • CD248, also known as endosialin or TEM1, has emerged as a significant therapeutic target.
  • Its function has been extensively studied over the past 30 years, revealing its potential in treating specific diseases.
  • CD248 plays a role in tissue structure by connecting different cell types within a multi-protein complex.

Purpose of the Study:

  • To review existing literature on CD248 (endosialin/TEM1) and its therapeutic potential.
  • To examine the expression patterns of CD248 in various preclinical models and cell line collections.
  • To highlight CD248 as a target for novel cancer therapies, especially for sarcomas and fibrotic diseases.

Main Methods:

  • Literature review on CD248 function and therapeutic targeting.
  • Analysis of CD248 expression in patient-derived xenografts and cell lines.
  • Examination of data from large cell line collections like CCLE and GDSC-MGH-Sanger.

Main Results:

  • CD248 is highly and selectively expressed in sarcomas.
  • It is also found in pericytes within tumor and wound-healing vasculature.
  • CD248 is overexpressed in several human solid tumors but largely absent in normal adult tissues.

Conclusions:

  • CD248 (endosialin/TEM1) is a promising therapeutic target for sarcomas and fibrotic diseases.
  • Its selective expression profile makes it a potentially safe target for radioimmunotherapy.
  • Further exploration of CD248 in cancer therapy, particularly for Ewing's sarcoma, is warranted.

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