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Updated: May 6, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
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Engineering organs-on-a-chip via multi-channel microfluidics.

Ji Qiu1, Jia Yang2,3, Lihao Liu2,3

  • 1School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, China. lingmubai@ujs.edu.cn.

Lab on a Chip
|February 19, 2026
PubMed
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This summary is machine-generated.

Organ-on-a-chip (OoC) technology uses multi-channel microfluidic chips to create advanced human physiology models. This innovation improves drug testing and disease modeling by overcoming limitations of traditional methods.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Tissue Engineering

Background:

  • Conventional in vitro models (animal studies, 2D/3D cell cultures) face limitations like interspecies differences, ethical concerns, and poor physiological replication.
  • Organ-on-a-chip (OoC) technology offers a solution by mimicking organ-specific microphysiological systems.
  • Multi-channel microfluidic chips are central to OoC, enabling 3D tissue formation and dynamic factor modulation.

Purpose of the Study:

  • To systematically review the development of Organ-on-a-chip technology.
  • To focus on the role of multi-channel microfluidics in OoC advancements.
  • To provide a reference for technological iteration and interdisciplinary applications of microfluidic chip systems.

Main Methods:

  • Review of Organ-on-a-chip (OoC) technology development.

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  • Focus on multi-channel microfluidic chip systems.
  • Examination of biomimetic design, fabrication methods, applications, and challenges.

    • Main Results:

    • OoC technology, utilizing multi-channel microfluidics, enables the creation of functional models (e.g., lung alveoli, blood-brain barrier, cardiac tissues).
    • These models advance drug testing, disease modeling, and toxicological assessments.
    • Key domains reviewed include biomimetic design, fabrication (soft lithography, 3D printing), and applications.

    Conclusions:

    • Organ-on-a-chip technology represents a significant advancement over conventional in vitro models.
    • Multi-channel microfluidics are crucial for the design, fabrication, and application of OoCs.
    • Further development in structural design, materials, fabrication, and biological applications is expected.