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Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: May 11, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Detecting glaucoma progression through optic nerve head hemoglobin concentration using automated colorimetric

Verônica Vilasboas-Campos1,2, Alessandro A Jammal1,2, Gabriel Ayub1

  • 1Department of Ophthalmology, University of Campinas, Campinas, SP, Brazil.

European Journal of Ophthalmology
|February 19, 2026
PubMed
Summary
This summary is machine-generated.

An algorithm estimating hemoglobin (Hb) concentration changes in the optic nerve head (ONH) did not effectively detect glaucoma progression. Changes in the Globin Individual Pointer (GIP) over time were not associated with visual field changes in primary open-angle glaucoma (POAG) patients.

Keywords:
Diagnostic techniques < GLAUCOMAaqueous humor dynamics < GLAUCOMAhealth economics < GLAUCOMAocular blood flow < GLAUCOMAopen angle glaucoma < GLAUCOMA

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Published on: May 25, 2020

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Last Updated: May 11, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Early detection of glaucoma progression is crucial for timely intervention.
  • Current methods for monitoring glaucoma progression have limitations.

Purpose of the Study:

  • To evaluate an algorithm that quantifies hemoglobin (Hb) concentration changes in the optic nerve head (ONH).
  • To determine if this algorithm can detect progression in glaucomatous eyes with progressive visual field changes.
  • To assess the association between Hb concentration changes and visual field progression in primary open-angle glaucoma (POAG).

Main Methods:

  • Retrospective cohort study of 133 eyes with POAG.
  • Analysis of Standard Automated Perimetry (SAP) tests and ONH photos.
  • Utilized Laguna ONhE software for automated colorimetric analysis of Hb concentration in ONH.
  • Defined visual field progression using Humphrey perimeter's guided progression analysis (GPA).
  • Employed receiver operating characteristic curve (ROC) regression to assess Globin Individual Pointer (GIP) performance.

Main Results:

  • 20% of eyes showed visual field progression over an average follow-up of 2.4 years.
  • No significant difference in median Hb concentration (GIP) change between progressing and non-progressing eyes.
  • GIP changes over time were not significantly associated with visual field progression.
  • Area under the ROC curve for GIP change to detect progression was 0.49.

Conclusions:

  • Hb concentration estimates from fundus photos did not significantly differ between progressing and non-progressing eyes.
  • GIP changes over time were not associated with visual field progression in POAG.
  • The current method requires improvement for effective glaucoma progression detection.