Related Experiment Video
Updated: Feb 21, 2026
06:26
Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
952
Metabolic Dysfunction-Associated Steatotic Liver Disease in Pregnancy: A Review
Daniel Core1, Layne Landry1, Christopher Menefee1
1Resident, Department of OBGYN.
Obstetrical & Gynecological Survey
|February 19, 2026
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in pregnancy and linked to adverse outcomes. Early detection and management are crucial for maternal and infant health.
Area of Science:
- Hepatology
- Maternal-Fetal Medicine
- Metabolic Disorders
Background:
- Metabolic dysfunction-associated steatotic liver disease (MASLD), previously nonalcoholic fatty liver disease, affects 14% of pregnant individuals.
- MASLD is linked to metabolic comorbidities like obesity and insulin resistance.
- It is associated with pregnancy complications, including gestational diabetes and hypertensive disorders.
Purpose of the Study:
- To review the pathophysiology, diagnosis, management, and pregnancy complications of MASLD.
- To highlight the increasing prevalence and underdiagnosis of MASLD in pregnant populations.
Main Methods:
- A literature search was performed using Rayyan.
- 180 articles published between 2000 and 2024 were reviewed.
Main Results:
- MASLD is increasingly prevalent and likely underdiagnosed during pregnancy.
- Obesity and pregnancy's physiological changes can worsen liver steatosis.
- MASLD is associated with adverse pregnancy and offspring outcomes.
Conclusions:
- Further research is needed for optimal screening, diagnosis, and management of MASLD in pregnancy.
- Early detection may warrant diabetes screening and low-dose aspirin.
- Counseling on risks like maternal morbidity, preterm birth, and offspring metabolic disease is essential.
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