Related Experiment Video
Updated: May 5, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Self-assembled 8-shogaol/curcumin nanoparticles via hydrogen bonding: enhanced stability and sustained release in
Rui Zhang1, Jing-Yu Feng1, Kiran Thakur2
1School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China.
Abstract:
This study synthesized curcumin/polyvinyl pyrrolidone (PVP)/8-shogaol nanoparticles (PCS-NPs) loaded with 8-shogaol using hydrogen bonding self-assembly. Firstly, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), 1H NMR spectrometer and other techniques were used to characterize the size and molecular structure of PCS-NPs. The optimized PCS-NPs exhibited a particle size of 82.58 nm, a zeta potential of -22.4 mV, an encapsulation efficiency of 81.4%, and a loading capacity rate of 15.08%. Molecular dynamics simulations elucidated the mode of hydrogen bonding interactions within the PCS-NPs. Stability analysis revealed that PCS-NPs possessed superior storage stability and demonstrated remarkable stability under temperature and UV irradiation conditions. PCS-NPs exerted higher release efficiency in the intestine as well as higher intestinal transport efficiency. This study laid the theoretical foundation for enhancing the solubility, stability, and bioaccessibility of 8-Shogaol.
More Related Videos
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Site-Targeted Drug Delivery Systems: Polymeric Carriers

