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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

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Bowel Disorders.

Maura Corsetti1, Andrea Shin2, Brian E Lacy3

  • 1NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham Digestive Diseases Biomedical Research Centre, Nottingham, United Kingdom.

Gastroenterology
|February 19, 2026
PubMed
Summary
This summary is machine-generated.

The Rome V classification updates Bowel Disorders (BDs) diagnosis, offering new insights into their causes and treatments. This revised framework aims to improve patient care and research for these prevalent conditions.

Keywords:
Abdominal PainBloatingConstipationDiarrhea

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Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Epidemiology

Background:

  • Bowel Disorders (BDs), formerly functional bowel disorders, are globally prevalent, impacting quality of life and incurring significant economic costs.
  • Recent research since the Rome IV criteria (2016) has advanced understanding of BDs' epidemiology, etiology, pathophysiology, diagnosis, and treatment.

Purpose of the Study:

  • To present the updated Rome V classification for Bowel Disorders.
  • To provide a revised diagnostic framework for BDs based on recent scientific advancements.

Main Methods:

  • Review and synthesis of current research in basic and clinical sciences related to BDs.
  • Development of revised diagnostic criteria by the Rome V BD Committee.

Main Results:

  • The Rome V classification defines 6 distinct BD categories: irritable bowel syndrome, chronic constipation, functional diarrhea, functional abdominal bloating, unclassified BD, and opioid-induced constipation.
  • Each category includes updated definitions, epidemiology, rationale for changes, clinical evaluation, pathophysiology, and treatment strategies.

Conclusions:

  • The Rome V classification offers an updated framework to enhance the diagnosis and management of Bowel Disorders.
  • This revision is expected to aid clinicians and researchers in advancing patient care and scientific understanding of these common conditions.