Live biotherapeutics and nutraceuticals: Exploring the differences and synergies

Area of Science:

• Microbiology
• Gastroenterology
• Pharmacology

Background:

• The human gut microbiome is increasingly recognized as a therapeutic target for health and well-being.
• Novel interventions like live biotherapeutic products (LBPs) and nutraceuticals have emerged.

Purpose of the Study:

• To provide insights into the nature, purpose, and regulatory aspects of LBPs and nutraceuticals.
• To explore potential coformulation applications for improved health outcomes.

Main Methods:

• Comparative analysis of LBPs and nutraceuticals.
• Review of regulatory pathways for each intervention type.
• Exploration of coformulation strategies.

Main Results:

• LBPs comprise live microorganisms regulated as therapeutics for specific diseases.
• Nutraceuticals are food-derived or phytonutrients for general health improvement and prevention.
• Distinct regulatory pathways exist for LBPs and nutraceuticals.

Conclusions:

• LBPs and nutraceuticals represent different approaches to modulating the gut microbiome.
• Understanding their unique characteristics is crucial for appropriate application.
• Coformulation may offer synergistic benefits for enhanced health outcomes.