BreasTransNeXt: An Enhanced Multi-Module Vision Transformer For Early Breast Cancer Diagnosis
Hakan Acikgoz1, Alper Aytekin2, Sevgi Gezici3
1Department of Software Engineering, Faculty of Engineering, Architecture and Design, Kahramanmaras Istiklal University, Kahramanmaras, 46050, Turkey. hakan.acikgoz@istiklal.edu.tr.
Journal of Imaging Informatics in Medicine
|February 19, 2026
Summary
A new deep learning model, BreasTransNeXt, improves early breast cancer (BC) detection by combining convolutional and transformer architectures. This advanced framework enhances feature extraction and model generalization for more accurate BC classification.
Area of Science:
- Medical Imaging and Diagnostics
- Artificial Intelligence in Healthcare
- Oncology
Background:
- Breast cancer (BC) is a leading cause of cancer mortality in women worldwide, making early diagnosis crucial for improved treatment outcomes.
- Existing deep learning models for BC classification often lack comprehensive feature extraction and balanced learning, hindering diagnostic accuracy.
- There is a need for advanced AI frameworks that can effectively integrate multi-scale feature representation and address class imbalance in BC datasets.
Purpose of the Study:
- To introduce BreasTransNeXt, a novel hybrid deep learning framework designed for robust and accurate breast cancer classification.
- To enhance feature representation by synergizing convolutional and transformer architectures for multi-scale analysis of BC images.
- To address the challenge of class imbalance in BC datasets using advanced data augmentation techniques.
Main Methods:
- Developed BreasTransNeXt, a hybrid deep learning model combining ConvFormer's convolutional inductive bias with a transformer's global attention mechanisms.
- Employed Wasserstein Generative Adversarial Network with gradient penalty for data augmentation, generating high-fidelity synthetic images to balance malignant and healthy classes.
- Integrated a hybrid attention mechanism (local, channel, global branches with adaptive gating) to capture fine-grained lesion characteristics and long-range dependencies.
Main Results:
- BreasTransNeXt achieved superior performance compared to traditional Convolutional Neural Network (CNN) and Vision Transformer (ViT) models.
- The model demonstrated high accuracy (0.9710), recall (0.9808), precision (0.9808), and F1-score (0.9808) in breast cancer classification.
- Experimental results validate the effectiveness of the hybrid architecture and attention mechanisms in enhancing feature representation and model generalization.
Conclusions:
- BreasTransNeXt offers a significant advancement in deep learning for breast cancer detection, providing robust multi-scale feature representation and effective class imbalance mitigation.
- The proposed framework shows strong potential as a reliable tool for early and accurate breast cancer diagnosis, improving upon existing AI methodologies.
- Further research can explore the clinical integration of BreasTransNeXt to aid radiologists and improve patient outcomes in breast cancer screening.
Keywords:
Breast cancerDeep learningHybrid attentionVision transformerWasserstein Generative Adversarial Network

