Effects of Additional Administration of Vitamin D Formula with Anti-Muscarinic Agent for Patient with Overactive...

We aimed to confirm the effects of additional administration of vitamin D formula with anti-muscarinic drugs for improving overactive bladder symptoms in overactive bladder patients with vitamin D deficiency using a double blind randomized controlled trial.

The study population was 1:1 randomly assigned: a treatment group receiving combined propiverine HCl 10 mg and cholecalciferol 1,000 IU daily, and a control group receiving propiverine HCl 10 mg and placebo. Primary outcome was determined as the changes in total overactive bladder symptom score at 4- and 8-weeks after administration of vitamin D preparations.

A total of 24 individuals were included for the study and there was no statistically significant difference in the baseline characteristics between groups. After administration serum 25(OH) vitamin D level was higher in the treatment group at post-treatment 4-weeks (12.7 vs. 21.3 ng/mL, p=0.019) and post-treatment 8-weeks (14.4 vs. 22.6 ng/mL, p=0.008). Total overactive bladder symptom score was significantly reduced in treatment group at post-treatment 4-weeks (-1.2 vs. -4.3, p=0.002) and 8-weeks (-1.6 vs. -4.0, p=0.042) compared to control group.

Combined administration of a daily parenteral anti-muscarinic agent and a vitamin D formula improved overactive bladder symptoms in individuals with overactive bladder and vitamin D deficiency compared to administration of an anti-muscarinic agent and placebo. This study confirmed that supplementation of vitamin D might be helpful for relieving overactive bladder symptoms in patients with vitamin D deficiency.