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Algorithm-Empowered Photocontrolled DNA Origami Nanostructures for Information Encryption
Mengyao Sun1,2,3,4, Bo Kou5, Mo Xie1,2,3
1State Key Laboratory for Flexible Electronics (LoFE), Nanjing University of Posts and Telecommunications, Nanjing 210023, China.
Journal of the American Chemical Society
|February 20, 2026
Summary
Researchers developed a novel bioalgorithmic security framework using photocontrolled DNA origami nanostructures for advanced information encryption. This dynamic, multimechanism approach enhances data security beyond traditional methods.
Area of Science:
- Biotechnology
- Information Security
- Nanotechnology
Background:
- Traditional encryption methods face limitations in physical protection, flexibility, and key management due to increasing data volumes and sophisticated threats.
- Static, single-mechanism encryption is insufficient for modern information security needs.
- Dynamic, multi-mechanism collaborative defense is essential for robust information security.
Purpose of the Study:
- To develop an algorithm-empowered encryption strategy using photocontrolled DNA origami nanostructures.
- To establish a bioalgorithmic collaborative security framework integrating algorithms with molecular-scale structural reconfiguration.
- To enhance information security through dynamic, molecular-level encryption and programmatic control.
Main Methods:
- Utilized rectangular DNA origami nanostructures as physical substrates for information steganography via binary mapping.
- Employed azobenzene-modified DNA strands as dynamic connectors, regulated by ultraviolet-visible (UV-vis) irradiation for interstructural state control.
- Embedded classical substitution-permutation ciphers within DNA nanostructures and integrated computational algorithms for key management and optimization.
Main Results:
- Demonstrated molecular-level information encryption and programmatic control through dynamic nanostructure reconfiguration.
- Achieved enhanced information confusion and diffusion via cooperative encryption mechanisms.
- Computational algorithms optimized key layout and performed heuristic searches for secure molecular-level information processing.
Conclusions:
- The developed photocontrolled DNA origami nanostructure strategy offers a promising bioalgorithmic approach to information security.
- This method integrates molecular programming with classical ciphers for dynamic, secure data handling.
- The research opens new perspectives for biointegrated intelligent systems and advanced information security solutions.
