Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Packaging

DNA Packaging

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Innate Immunity of Framework Nucleic Acids.

Accounts of chemical research·2026

Same author

A multiple-encrypted DNA device for secure communication.

Science advances·2026

Same author

Regarding "Deteriorated Quality and Media Retraction of Tendon Following Acute Traumatic Rotator Cuff Tear Are Predictors of Retear After Arthroscopic Repair".

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026

Same author

Programming Dimensional Transitions in DNA Brick Crystals via Interfacial Connectivity.

Angewandte Chemie (International ed. in English)·2026

Same author

Amplifying tumour antigen presentations from intratumourally entrapped dendritic cells.

Nature nanotechnology·2026

Same author

Controlled electrochemical deposition of metal nanostructures on DNA origami templates.

Chemical communications (Cambridge, England)·2026

Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026

Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026

Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026

Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026

Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026

Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 21, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Algorithm-Empowered Photocontrolled DNA Origami Nanostructures for Information Encryption.

Mengyao Sun^1,2,3,4, Bo Kou⁵, Mo Xie^1,2,3

¹State Key Laboratory for Flexible Electronics (LoFE), Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Journal of the American Chemical Society

|February 20, 2026

Summary

This summary is machine-generated.

Researchers developed a novel bioalgorithmic security framework using photocontrolled DNA origami nanostructures for advanced information encryption. This dynamic, multimechanism approach enhances data security beyond traditional methods.

More Related Videos

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Related Experiment Videos

Last Updated: Feb 21, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Area of Science:

Biotechnology
Information Security
Nanotechnology

Background:

Traditional encryption methods face limitations in physical protection, flexibility, and key management due to increasing data volumes and sophisticated threats.
Static, single-mechanism encryption is insufficient for modern information security needs.
Dynamic, multi-mechanism collaborative defense is essential for robust information security.

Purpose of the Study:

To develop an algorithm-empowered encryption strategy using photocontrolled DNA origami nanostructures.
To establish a bioalgorithmic collaborative security framework integrating algorithms with molecular-scale structural reconfiguration.
To enhance information security through dynamic, molecular-level encryption and programmatic control.

Main Methods:

Utilized rectangular DNA origami nanostructures as physical substrates for information steganography via binary mapping.
Employed azobenzene-modified DNA strands as dynamic connectors, regulated by ultraviolet-visible (UV-vis) irradiation for interstructural state control.
Embedded classical substitution-permutation ciphers within DNA nanostructures and integrated computational algorithms for key management and optimization.

Main Results:

Demonstrated molecular-level information encryption and programmatic control through dynamic nanostructure reconfiguration.
Achieved enhanced information confusion and diffusion via cooperative encryption mechanisms.
Computational algorithms optimized key layout and performed heuristic searches for secure molecular-level information processing.

Conclusions:

The developed photocontrolled DNA origami nanostructure strategy offers a promising bioalgorithmic approach to information security.
This method integrates molecular programming with classical ciphers for dynamic, secure data handling.
The research opens new perspectives for biointegrated intelligent systems and advanced information security solutions.