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Characterisation of Three Novel HLA Class II Alleles Identified in Bone Marrow Donors by Next-Generation Sequencing

Aida Turganbekova1,2, Zhulduz Zhanzakova1, Dana Baimukasheva1

  • 1Scientific and Production Center of Transfusiology, Astana, Kazakhstan.

HLA
|February 20, 2026
PubMed

Abstract:

We report three novel HLA class II alleles, DRB1*14:284N, DQA1*05:131 and DPB1*1826:01.

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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