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Unusual Presentation of Plexiform Neurofibroma Embedded with Large Comedones: A Case Report
Waseem Alhawsawi1, Wafa Alghamdi1, Maria AlSulami2
1King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
Case Reports in Dermatology
|February 20, 2026
Summary
This case report details an unusual plexiform neurofibroma (PNF) in a neurofibromatosis type 1 (NF1) patient, featuring large comedones. This rare dermatological presentation highlights the need for awareness of atypical NF1 manifestations.
Area of Science:
- Dermatology
- Oncology
- Genetics
Background:
- Plexiform neurofibromas (PNFs) are benign neoplasms associated with neurofibromatosis type 1 (NF1).
- NF1 is a genetic disorder caused by NF1 gene mutations, leading to dysregulated Ras signaling and uncontrolled cell growth.
- PNFs can involve extensive nerve plexuses and have malignant potential.
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