Age-Stratified Differences in Cardio-Reno-Metabolic Risk Profiles

Area of Science:

• Gerontology
• Cardiovascular Medicine
• Nephrology
• Metabolic Syndrome

Background:

• Cardio-reno-metabolic disorder susceptibility increases with age.
• Risk factors evolve across the adult lifespan, with metabolic issues dominating younger ages and vascular/renal changes in older populations.
• Understanding age-related risk reconfiguration can inform tailored prevention strategies.

Purpose of the Study:

• To investigate age-stratified differences in cardio-reno-metabolic risk profiles.
• To identify dominant risk markers across different adult age groups.
• To inform life-course approaches to risk assessment and prevention.

Main Methods:

• Cross-sectional observational study of 287 adults.
• Participants stratified into three age groups: <65, 65-75, and >75 years.
• Assessed anthropometrics, blood pressure, metabolic parameters, liver enzymes, inflammatory markers, renal function (eGFR, UACR), and insulin resistance (TyG index).

Main Results:

• Younger adults (<65) showed a metabolic profile (higher BMI, glucose, triglycerides, TyG index).
• Older adults (>65) exhibited a vascular-renal phenotype (higher SBP, lower DBP, declining eGFR).
• Liver enzymes decreased with age; FIB-4 index increased; UACR and CRP showed no significant age differences.

Conclusions:

• Cardio-reno-metabolic risk profiles exhibit distinct age-stratified patterns.
• Metabolic risk predominates in younger adults, while vascular and renal vulnerability increase with age.
• Early detection of vascular/microvascular risk in younger individuals is crucial for preventing advanced renal and vascular aging.