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Atrial Septal Defect Surgical Closure Following Trametinib Utilization in Noonan Syndrome-Associated Hypertrophic

Camden Hebson1, Sydney Escott2, Guillermo Beltran-Ale3

  • 1Division of Pediatric Cardiology, Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

JACC. Case Reports
|February 20, 2026
PubMed
Summary

Trametinib effectively treated severe Noonan syndrome-associated hypertrophic cardiomyopathy (NS-HCM) in an infant. Subsequent surgical closure of an atrial septal defect led to full recovery and discharge.

Keywords:
MEK inhibitionNoonan syndromeRASopathyatrial septal defectcardiac surgeryhypertrophic cardiomyopathy

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