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Related Experiment Video

Updated: Feb 22, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
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Strontium-substituted bioglass-based composite for restoring root surface defects.

Diana Abduallah1, Richard M Shelton2, Michael R Milward2

  • 1Dentistry, College of Medicine and Health, University of Birmingham, Birmingham, UK; Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Dental Materials : Official Publication of the Academy of Dental Materials
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

A novel strontium-bioglass composite material significantly enhanced oral keratinocyte attachment compared to traditional resin materials. This improved cellular interaction may help restore the gingival seal around teeth with root surface lesions.

Keywords:
BioglassCellular attachmentCompositeGingival sealRoot-defects

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Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Cell Biology

Background:

  • The interaction between soft tissues and resin-based dental restorations is not fully understood.
  • This knowledge gap is critical for restoring root surface lesions near the gingiva, impacting clinical success.
  • This study investigates cellular interactions with a new resin material compared to existing ones.

Purpose of the Study:

  • To evaluate cellular interactions with a novel strontium-substituted bioglass (Sr-BG) filled resin.
  • To compare the cellular compatibility of the Sr-BG resin with resin-modified glass ionomer (RMGI) and resin composites.
  • To assess the impact of material leachates on oral keratinocyte attachment.

Main Methods:

  • Tested RMGI, resin composites, and a novel Sr-BG resin.
  • Performed bulk and leachate characterizations.
  • Quantitatively and qualitatively assessed oral keratinocyte attachment to fresh and aged specimens using trypan-blue assay and SEM.

Main Results:

  • Differences in resin and filler composition influenced leaching and cellular attachment.
  • Significantly more cells attached to the Sr-BG material, showing enhanced spreading and cell-cell contacts.
  • Positive correlations observed between cell attachment and pH, Si⁴⁺, and Sr²⁺ ion release; negative correlations with Al³⁺ ion release.

Conclusions:

  • The novel Sr-BG composite demonstrated potential for managing root surface lesions.
  • The material promoted cellular attachment, potentially aiding in regaining the gingival seal.
  • This suggests a promising new material for restorative dentistry near the gingiva.