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Updated: Jul 11, 2026
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Pseudo-Richter Transformation Following BTKi Interruption in CLL: A Systematic Review of Clinical, Biological, and
Javier Marco-Ayala1, María Dolores García Malo1, Francisco J Ortuño1
1Servicio de Hematología, Centro Regional de Hemodonación, Hospital Universitario Morales Meseguer, IMIB-Pascual Parrilla, Universidad de Murcia, Murcia, Spain.
Background:
Pseudo-Richter transformation (pseudo-RT) is a rare and recently recognized phenomenon characterized by a transient large B-cell proliferation occurring shortly after interruption of Bruton tyrosine kinase inhibitor (BTKi) therapy in chronic lymphocytic leukemia (CLL). Although it closely mimics true Richter transformation (RT) clinically and histologically, pseudo-RT follows a distinct and reversible course, and its recognition is essential to avoid misdiagnosis and inappropriate treatment.
Methods:
We report a new case of pseudo-RT with circulating large atypical cells and present a systematic review of published cases.
Results:
Fifteen cases were identified. The median age at pseudo-RT onset was 72 years, and 87% of patients were male. All analyzed CLL IGHV sequences were unmutated (5/5 tested). Trisomy 12 was the most frequent cytogenetic abnormality (7/9, 78%), and TP53 disruption was present in 6 patients, including del(17p) and TP53 mutations. Pseudo-RT typically developed 3 to 13 days after BTKi interruption and most cases presented with lymphadenopathy, B symptoms, lymphocytosis, and elevated lactate dehydrogenase levels. Histological examination consistently demonstrated diffuse large B-cell proliferations with high Ki-67 expression (50-90%) and retained expression of CD5 and CD23, with a non-germinal center B-cell phenotype in all evaluable cases (9/9). Reintroduction of BTKi therapy resulted in complete clinical, laboratory, and radiologic resolution in all patients. No cases of subsequent RT were reported during follow-up (3-36 months).
Conclusion:
pseudo-RT is a reversible event, and awareness of its characteristic features is essential to prevent overtreatment.
