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Updated: Feb 22, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Diversity in CDK structural mechanisms of regulation and drug discovery opportunities

Rhianna J Rowland1, Martin E M Noble1, Jane A Endicott1

  • 1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

Trends in Biochemical Sciences
|February 20, 2026
PubMed

Keywords:
CDKX-ray crystallographycryogenic electron microscopycyclinsshort linear motifstructure-based drug design

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