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Updated: Feb 23, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Interference of long noncoding RNAs in glioblastoma multiforme: key targets for next generation therapeutics

Soushruti Sarkar1, Subhrangsu Chatterjee1

  • 1Department of Biological Sciences, Bose Institute, Kolkata 700091, India.

Drug Discovery Today
|February 21, 2026
PubMed

Insights

Long noncoding RNAs are crucial in glioblastoma multiforme (GBM) development and drug resistance. Targeting these RNAs offers new therapeutic strategies for this aggressive brain tumor.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor patient survival.
  • Uncontrolled progression and therapy resistance contribute to GBM's poor prognosis.

Purpose of the Study:

  • To review the role of long noncoding RNAs (lncRNAs) in glioblastoma multiforme (GBM) pathogenesis.
  • To explore lncRNAs' influence on GBM stemness, proliferation, angiogenesis, and therapy resistance.
  • To discuss therapeutic targeting of lncRNAs in GBM.

Main Methods:

  • Literature review focusing on lncRNAs in GBM.
  • Analysis of lncRNA mechanisms in drug resistance.
  • Examination of combinatorial treatment strategies involving lncRNAs.

Main Results:

  • lncRNAs significantly influence GBM stemness, gene expression, proliferation, angiogenesis, and therapy resistance.
  • lncRNAs modify cellular pathways contributing to drug resistance.
  • lncRNAs show tissue-specific expression and persistence in body fluids.

Conclusions:

  • lncRNAs are key players in GBM pathogenesis and drug resistance.
  • Targeting lncRNAs presents a promising therapeutic avenue for GBM.
  • Combinatorial treatments involving lncRNAs may improve therapeutic outcomes in GBM.
Keywords:
Glioblastomamultiformecancerlong noncoding RNAmRNAmiRNA spongingtemozolomidetumor

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