Related Experiment Video
Updated: Feb 23, 2026
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Gingivobuccal Squamous Cell Carcinoma: A Different Genomic Entity.
Janani Sambath1, Snehitha Achyutha2, Irene A George1
1Institute of Bioinformatics, International Technology Park, Bangalore, India; Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
Gingivobuccal mucosal squamous cell carcinoma (GBMSCC), linked to areca nut use, shows specific genetic mutations and immune cell changes. Understanding these molecular features aids in developing targeted therapies and early detection methods for this head and neck cancer.
Area of Science:
- Oncology
- Genomics
- Immunology
Background:
- Gingivobuccal mucosal squamous cell carcinoma (GBMSCC) is a distinct head and neck cancer.
- It is strongly associated with areca nut and smokeless tobacco use.
- Often arises in patients with oral submucous fibrosis.
Purpose of the Study:
- To elucidate the multiomics landscape of GBMSCC.
- To identify key molecular drivers and tumor microenvironment characteristics.
- To inform the development of targeted therapies and biomarkers.
Main Methods:
- Multiomics analyses including genomics, transcriptomics.
- Characterization of tumor microenvironment composition.
- Correlation of molecular findings with clinical context.
Main Results:
- Recurrent mutations identified in TP53, FAT1, CASP8, PIK3CA, and AAM pathway genes.
- Distinct copy number alterations and transcriptomic programs observed.
- Tumor microenvironment enriched with exhausted T cells, macrophages, and cancer-associated fibroblasts.
Conclusions:
- GBMSCC exhibits a unique molecular profile.
- Insights into genetic mutations and immune evasion mechanisms are crucial.
- Supports development of subsite-specific strategies for targeted therapy, immunotherapy, chemoprevention, and saliva-based biomarkers for early detection and improved outcomes.
More Related Videos
11:28Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Related Concept Videos
02:21Cancers Originate from Somatic Mutations in a Single Cell
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:33Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...