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Allostatic load in psychiatry: a systematic review and meta-analysis

Sabine Finlay1,2,3, Riana Marie1,2,4, Donna Rudd3

  • 1Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia.

Stress (Amsterdam, Netherlands)
|February 21, 2026
PubMed
Summary

The allostatic load (AL) model shows elevated AL in psychiatric disorders, particularly schizophrenia and psychosis. Major depressive disorder did not show a significant AL difference compared to healthy controls.

Keywords:
Psychiatric disordersallostatic loadbiomarkersmental healthmeta-analysissystemic dysregulation

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