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Updated: Feb 24, 2026

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
Published on: December 15, 2015
Recent advancements in liquid chromatography column technologies: Manufacturing, connecting and parallel using
Lin Lv1, Hanchen Cao1, Yeming Hu1
1Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen 361005, China.
Abstract:
The evolution of omics science and pharmaceutical research has driven the fast development of high-throughput liquid chromatography (HTLC). Among the various technologies enabling HTLC, column technology plays a crucial role - it directly increases analytical throughput while also securing the resolution of HTLC systems. This review summarizes recent key advancements in liquid chromatography column technologies for HTLC, focusing on three major aspects: column manufacturing, connecting, and parallel using. The integration and development of manufacturing, connecting and parallel using of chromatographic columns provide the underpinning support for the fields demanding high analytical throughput, such as single-cell proteomics, drug discovery, and large-scale screening analyses.
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