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Continuous twin screw wet granulation of low-dose formulations: Impact of process variables and API/binder addition

Louis Bouckaert1, Mathieu Ombecq1, Giorgia Adamo1

  • 1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

International Journal of Pharmaceutics
|February 22, 2026
PubMed

Keywords:
API/binder addition methodsCompartmental analysisContinuous manufacturingDesign of experimentsLow-dose formulationsTwin-screw wet granulationWeighted mean absolute deviation

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