Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

4.3K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
4.3K
Joints01:26

Joints

35.9K
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.9K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.5K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.5K
Introduction to Joints00:58

Introduction to Joints

5.1K
The adult human body usually has 206 bones, and except for the hyoid bone in the neck, each bone is connected to at least one other bone. Joints are the location where bones come together. Many joints allow for movement between the bones. At these joints, the articulating surfaces of the adjacent bones can move smoothly against each other. However, the bones of other joints may be joined by connective tissue or cartilage. These joints are designed for stability and provide little or no...
5.1K
Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

4.0K
Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
4.0K
Sutures of the Skull01:22

Sutures of the Skull

13.5K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
13.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving comparability of microCT assessment and reporting of subchondral bone in mouse models of osteoarthritis.

Osteoarthritis and cartilage·2026
Same author

Synchrotron tomography-based inversion pipeline for estimating elastic properties for rat vertebral endplate finite element models.

Acta biomaterialia·2026
Same author

Whole bone µCT 3-dimensional mapping reveals new early imaging biomarkers of osteoarthritis.

Osteoarthritis and cartilage·2026
Same author

Experimental menopause in 3xTg-AD mice exacerbates metabolic, inflammatory, and osteologic phenotypes aligned with Alzheimer's disease pathology.

Research square·2025
Same author

A deep learning-based framework for standardized analysis of trabecular bone compartments from micro-CT imaging data in the mouse tibia.

Scientific reports·2025
Same author

Development of a translational strategy for using TIMP-3 to inhibit aggrecanase activity in osteoarthritis.

Osteoarthritis and cartilage·2025
Same journal

Culturable microorganisms in preservation fluids of historical anatomical wet collections.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2026
Same journal

Trigeminal motor root anatomy from pons to foramen ovale and its surgical implications: A study using epoxy sheet plastination and three-dimensional reconstruction.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2026
Same journal

Advanced three-dimensional morphometric analysis of calvarial bones used in scaffold studies.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2026
Same journal

Accessory carpal bones - Scoping review with meta-analysis: Accessory bones around the scaphoid.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2026
Same journal

Towards an integrative understanding of the human temporalis muscle: Anatomical, histological, and imaging evidence.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2026
Same journal

A single-subject finite element study on the influence of root dislocation direction on inferior alveolar nerve stress during mesially impacted mandibular third molar extraction.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2026
See all related articles

Related Experiment Video

Updated: Feb 24, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

11.7K

Epiphyseal interfaces.

Andrew A Pitsillides1

  • 1Skeletal Biology Group, Comparative Biomedical Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK.

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
|February 22, 2026
PubMed
Summary
This summary is machine-generated.

Osteoarthritis (OA) progression is linked to early changes in articular calcified cartilage (ACC) and growth plate (GP) strain patterns. These findings reveal new insights into OA pathogenesis and epiphyseal stability.

Keywords:
Articular calcified cartilageBone MechanicsGrowth plateHyaline cartilageMicro-computed tomographyOsteoarthritisSynchrotron-computed tomography

More Related Videos

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.5K
Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.7K

Related Experiment Videos

Last Updated: Feb 24, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

11.7K
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.5K
Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.7K

Area of Science:

  • Orthopedics and Sports Medicine
  • Biomedical Imaging
  • Skeletal Biology

Background:

  • Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage breakdown and bone changes.
  • Early detection and understanding of OA pathogenesis are crucial for developing effective treatments.
  • The role of articular calcified cartilage (ACC) and growth plate (GP) in OA development is not fully understood.

Purpose of the Study:

  • To investigate the interconnected roles of articular and growth plate osteochondral interfaces in OA.
  • To elucidate early structural and biomechanical changes preceding OA development using advanced imaging.
  • To explore the mechanical function of growth plate structures in epiphyseal stability.

Main Methods:

  • Combined benchtop micro-computed tomography (microCT) and high-resolution synchrotron CT (sCT) imaging.
  • Digital Volume Correlation (DVC) analysis on loaded murine knee joints.
  • Finite element simulation to model strain patterns.

Main Results:

  • Bony sclerosis in OA is preceded by amplified regionalized expansion of ACC.
  • Altered osteocyte lacunae number and size observed in pre-OA and OA regions.
  • OA-prone mice exhibit high strain foci in the epiphyseal compartment, unlike healthy controls.
  • Intra-physeal GP bridges are mechanically sensitive, regulating strain transfer and enhancing epiphyseal stability.

Conclusions:

  • Excessive ACC formation is an early consequence of disrupted endochondral ossification, potentially driving OA.
  • Early strain accumulation in the epiphyseal compartment primes joints for degenerative progression.
  • Growth plate bridges are key structures for coordinating mechanical strain and ensuring epiphyseal stability.