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Molecular engineering of ionic organic phototheranostic agents for NIR-II imaging-guided synergistic phototherapy
Jianye Gong1, Yue Zhang1, Chen Lu1
1College of Chemistry and Chemical Engineering, College of Green Chemistry and Environment, Institutes of Biomedical Sciences, Inner Mongolia Key Laboratory of Synthesis and Application of Organic Functional Molecules, Inner Mongolia University, Hohhot 010021, P. R. China. jiangguoyu@mail.ipc.ac.cn.
Abstract:
We develop ionic small-molecule phototheranostics by molecular engineering of positive charges and hydrophilicity/hydrophobicity balance. The optimized agent, 2PyI, achieves balanced amphiphilicity, enabling efficient NIR-II emission, reactive oxygen species generation, and photothermal conversion. It facilitates high-resolution NIR-II imaging-guided synergistic photodynamic/photothermal therapy.

