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Sex Difference Has No Effect on Survival in Pancreatic Cancer
1Department of Medical Oncology, Institute of Oncology, University of Istanbul, Capa, 34390 Istanbul, Turkey.
Indian Journal of Surgical Oncology
|February 23, 2026
Summary
This study found no significant difference in pancreatic cancer survival rates between men and women. Sex does not appear to impact overall survival in pancreatic cancer patients across all disease stages.
Area of Science:
- Oncology
- Cancer Research
- Clinical Significance of Sex in Cancer
Background:
- The clinical impact of sex on pancreatic cancer outcomes remains controversial.
- Previous studies have yielded conflicting results regarding sex-based differences in pancreatic cancer.
Purpose of the Study:
- To investigate the clinical significance of sex in pancreatic cancer patients.
- To determine if sex influences survival rates and clinical variables in pancreatic cancer.
Main Methods:
- Retrospective analysis of 334 pancreatic cancer patients.
- Assessment of sex distribution across different disease stages (local, locally advanced, metastatic).
- Evaluation of serum lactate dehydrogenase (LDH) levels and overall survival rates by sex.
Main Results:
- No significant difference in sex distribution across disease stages (p=0.9).
- Women with metastatic pancreatic cancer showed higher serum LDH levels than men (p=0.009).
- Overall survival rates were similar between sexes across all disease stages (metastatic p=0.2, locally advanced p=0.6, local p=0.09).
Conclusions:
- Sex was not found to significantly affect overall survival in pancreatic cancer patients.
- While higher LDH levels were observed in women with metastatic disease, this did not translate to survival differences.
- The findings suggest that sex is not a determining factor for survival in pancreatic cancer.
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