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Updated: Feb 24, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Electroreductive Nickel-Catalyzed Intramolecular Hydrosilylation of Alkenes
Mathias Reboli1, Muriel Durandetti1
1Univ. Rouen Normandie, INSA Rouen Normandie, Univ. Caen Normandie, ENSICAEN, CNRS, Institut CARMeN UMR 6064, Rouen F-76000, France.
A new electrochemical method synthesizes silylated heterocycles efficiently. This scalable process uses nickel catalysis for intramolecular hydrosilylation, offering broad applications in chemistry and materials science.
Area of Science:
- Organic Chemistry
- Electrochemistry
- Catalysis
Background:
- Silylated heterocycles are valuable building blocks.
- Efficient synthesis methods are crucial for their application.
- Existing methods may lack scalability or efficiency.
Purpose of the Study:
- To develop a highly efficient and scalable synthesis for novel silylated heterocycles.
- To explore the application of electrochemical methods in organic synthesis.
- To investigate the mechanism of the proposed reaction.
Main Methods:
- Nickel-catalyzed electrochemical intramolecular hydrosilylation of alkenes.
- Utilizing arylsilanes as substrates.
- Employing a sacrificial anode process for scalability.
Main Results:
- High regioselectivity in the conversion of arylsilanes.
- Exclusive Si-H addition to the carbon-carbon double bond via 5-exo-trig cyclization.
- Successful gram-scale synthesis demonstrated.
Conclusions:
- The reported method offers an efficient and scalable route to silylated heterocycles.
- The electrochemical approach provides a sustainable alternative for synthesis.
- The findings have potential applications in medicinal chemistry, fragrances, and materials science.
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