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Published on: October 12, 2015
H2O2‑Responsive Organic Small-Molecule MRI Probes for Acute Kidney Injury Imaging and Detection
Rulong Chen1,2, Shangpo Yang3,4, Duyang Gao3
1Department of Nephrology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen Hospital of Guangdong Provincial People's Hospital, the Affiliated Baoan Hospital of Southern Medical University, Shenzhen Baoan Clinical Medical School of Guangdong Medical University, The Eighth people's Hospital of Shenzhen, Baoan Clinical Research Center for Kidney Disease, Shenzhen, 518000, PR China.
Abstract:
Magnetic resonance imaging (MRI) has high temporal and spatial resolution without exposing patients to radiation, which shows great potential for acute kidney injury (AKI) detection. Typically, MRI uses gadolinium-based contrast agents to increase local signal intensity by distinguishing tissues or organs that are magnetically similar but histologically distinct, which might induce nephrotoxicity risks. In this work, we explored the potential application of easily available nitroxide-based organic radicals as an intravenously injectable MRI contrast agent. Different from the traditional accumulation-based MRI contrast agents, these organic radicals showed redox-responsive turn-off MRI signals to urinary hydrogen peroxide (H2O2) with ultrafast renal-clearable ability, which provides a new approach to design reaction-based small molecular organic MRI contrast agents for redox-related diagnostic applications.
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