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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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PRECISE TBI Model Catalog: Increasing Accessibility and Reproducibility in TBI research.

Monique C Surles-Zeigler1,2, Lauren Holmes1, Troy Sincomb1

  • 1Department of Neuroscience, School of Medicine, University of California at San Diego.

Biorxiv : the Preprint Server for Biology
|February 23, 2026
PubMed
Summary

The PRECISE-TBI model catalog centralizes data from over 450 preclinical traumatic brain injury (TBI) studies. This resource improves study design and reproducibility by standardizing reporting of critical variables.

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Area of Science:

  • Neuroscience
  • Biomedical Research
  • Data Science

Background:

  • Preclinical traumatic brain injury (TBI) research faces challenges in clinical translation due to fragmented resources and inconsistent reporting of experimental variables.
  • Existing experimental models for TBI vary significantly in mechanism, parameters, species, and age, hindering cross-study comparisons and reproducibility.

Purpose of the Study:

  • To introduce the PRECISE-TBI model catalog, a centralized and queryable resource for consolidating metadata from published preclinical TBI studies.
  • To enhance transparency, reproducibility, and data sharing in TBI research by integrating curated annotations and linking to protocols and datasets.

Main Methods:

  • Developed a centralized catalog by integrating curated annotations from over 450 published preclinical TBI studies.
  • Consolidated metadata including age, sex, strain, model type, device, and injury parameters for each study.
  • Linked catalog entries to available protocols and datasets to promote FAIR data principles.

Main Results:

  • Analysis revealed initial gaps in reporting critical variables such as device, age, and weight.
  • Reporting of sex has improved significantly, with over 90% of recent studies including this information.
  • Strain reporting is generally consistent, particularly for the C57 mice substrain.

Conclusions:

  • The PRECISE-TBI model catalog serves as a valuable tool for enhancing study design and reproducibility in preclinical TBI research.
  • The catalog facilitates cross-study comparisons, identifies reporting gaps, and connects literature to essential resources like protocols and datasets.
  • This initiative advances FAIR data principles within the TBI research community.