Related Experiment Video
Updated: Feb 24, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Spontaneous atraumatic splenic rupture secondary to infectious mononucleosis
Presentation:
A healthy 23-year-old man developed sore throat and fever with positive EBV Infectious Mononucleosis test, followed by abdominal pain, vomiting, and haemodynamic collapse, without trauma.
Diagnosis:
Bedside ultrasound suggested intraperitoneal free fluid. Urgent contrast-enhanced CT demonstrated large haemoperitoneum, perisplenic and subcapsular haematoma, and active splenic contrast extravasation.
Treatment:
Emergency laparotomy revealed massive haemoperitoneum, and confirmed splenic bleeding; splenectomy was performed. Recovery was uncomplicated, with post-splenectomy antibiotics and vaccinations. He was well at three-month follow-up.
Discussion:
EBV-associated atraumatic splenic rupture is rare yet life-threatening. CT imaging confirms injury and bleeding. Management depends on physiology; unstable patients require prompt surgical management, whereas stable cases may merit spleen-preserving strategies and close monitoring.
More Related Videos
Related Concept Videos
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Endocarditis II: Clinical Features of Infective Endocarditis
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Myocarditis I: Introduction

