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Updated: May 12, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Establishment and characterization of a novel sinonasal adenosquamous carcinoma cell line, TC717, with a high tumor
Ryosuke Kuga1,2, Takeo Yamamoto2, Takeshi Iwasaki2
1Department of Otorhinolaryngology-Head and Neck Surgery, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Abstract:
We established and characterized a novel human sinonasal adenosquamous carcinoma (ASC) cell line, TC717, derived from a 64-year-old, never-smoking woman. The patient received neoadjuvant chemotherapy followed by total maxillectomy but succumbed to disease 6 months after therapy initiation. TC717 recapitulated the histologic and immunohistochemical hallmarks of ASC, including squamous differentiation (p40 positivity) and mucin production. The cells displayed a stable doubling time of ~ 27 h. WES revealed a high TMB in both the primary tumor tissue (43.0 mut/Mb) and the TC717 cell line (34.0 mut/Mb), and pathogenic TP53 c.614A > G and BRAF c.1574 T > C variants, neither previously reported in ASC. TC717 provides a valuable preclinical platform for investigating sinonasal ASC biology and for evaluating genotype-directed therapies.
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