Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

500
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
500
Relative Risk01:12

Relative Risk

2.3K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.3K
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

459
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
459
Causality in Epidemiology01:21

Causality in Epidemiology

1.8K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.8K
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

1.4K
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.4K
Hazard Ratio01:12

Hazard Ratio

656
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
656

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Trust-Building Communication for Extreme Heat Preparedness.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same journal

Spring Broken: A Risk Analysis of Fatal and Nonfatal Traffic Injuries in Florida.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same journal

Global Sensitivity Analysis of Societal Resilience Using Shapley Values and Polynomial Chaos Expansion.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same journal

Assessing How Fact-Checks Influence Accuracy and Consensus Judgments: Evidence From the Olympics.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same journal

Applying the Bow Tie Method to Evaluate Emerging Risk: The Case of Carbon Capture and Water Stress.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same journal

Quantitative Microbial Risk Assessment of Human H5N1 Infection From Consumption of Fluid Cow's Milk.

Risk analysis : an official publication of the Society for Risk Analysis·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.7K

Combining Diverse Expert Opinions in Risk Analysis Using Relative Causal Knowledge.

Louis Anthony Cox1,2,3

  • 1Cox Associates, Denver, Colorado, USA.

Risk Analysis : an Official Publication of the Society for Risk Analysis
|February 24, 2026
PubMed
Summary
This summary is machine-generated.

Expert disagreement in risk analysis is common. A new framework, Relative Causal Knowledge for Expert Resolution (RCKER), helps reconcile differing expert causal models without forcing consensus, preserving unique insights.

Keywords:
causal abstractionexpert resolutioninterventional consistencyrelative causal knowledgestructural causal models

More Related Videos

Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.9K
Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
13:04

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods

Published on: September 19, 2012

12.5K

Related Experiment Videos

Last Updated: Feb 25, 2026

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.7K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.9K
Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
13:04

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods

Published on: September 19, 2012

12.5K

Area of Science:

  • Causal inference
  • Risk analysis
  • Decision theory

Background:

  • Expert disagreement is prevalent in risk analysis due to varied data, causal assumptions, and abstraction levels.
  • Traditional consensus methods can obscure critical differences in expert understanding.
  • There is a need for principled methods to manage expert disagreements in scientific and regulatory contexts.

Purpose of the Study:

  • To introduce a novel knowledge-based framework, Relative Causal Knowledge for Expert Resolution (RCKER), for managing expert disagreements.
  • To provide tools for translating, comparing, diagnosing, and reconciling differences in expert causal models.
  • To evaluate the reconcilability of expert models without assuming consensus is always possible.

Main Methods:

  • Utilizing causal inference and category theory to analyze expert causal models.
  • Treating each expert model as a partial perspective.
  • Identifying structural and interventional consistency across models.
  • Evaluating reconcilability at different levels of abstraction.

Main Results:

  • RCKER demonstrated conditional compatibility between expert models on PM2.5 health effects after abstraction and confounder alignment.
  • RCKER identified irreconcilable structural and interventional differences between models on formaldehyde and leukemia.
  • The framework successfully managed expert disagreement without forcing a misleading consensus.

Conclusions:

  • RCKER offers a principled approach to understanding and managing expert disagreement in risk analysis.
  • The framework preserves substantively distinct expert views, avoiding the pitfalls of forced consensus.
  • Findings have implications for risk communication, regulatory policy, and AI-assisted review tools.