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Related Concept Videos

Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Chronic Wound Healing: Breakthrough Strategies Based on Inorganic Polyphosphate.

Werner E G Müller1, Meik Neufurth2, Hadrian Nassabi3

  • 1ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. wmueller@uni-mainz.de.

Progress in Molecular and Subcellular Biology
|February 24, 2026
PubMed
Summary
This summary is machine-generated.

Chronic wound healing requires energy, often supplied by polyphosphate (polyP). Topical synthetic polyP and polyP nanoparticles can restore energy supply, aiding treatment for difficult wounds.

Keywords:
ATPAngiogenesisCalcium carbonateCell migrationChronic wound healingCoacervateInorganic polyphosphateMetabolic energyNanoparticlesRegenerative activity

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Area of Science:

  • Biochemistry
  • Wound Healing Research
  • Nanomedicine

Background:

  • Wound healing is an energy-intensive biological process.
  • Platelet-derived inorganic polyphosphate (polyP) is crucial for generating cellular energy (ATP).
  • Metabolic diseases, circulatory issues, and infections can impair energy supply, leading to chronic wounds.

Purpose of the Study:

  • To investigate the therapeutic potential of synthetic polyP formulations for chronic wound treatment.
  • To evaluate the efficacy of polyP and polyP nanoparticles in addressing energy deficits in wound healing.
  • To explore amorphous calcium carbonate particles stabilized with polyP as a novel therapeutic delivery system.

Main Methods:

  • Topical application of synthetic polyP.
  • Administration of amorphous polyP nanoparticles.
  • Utilizing polyP-stabilized amorphous calcium carbonate particles.

Main Results:

  • Synthetic polyP and polyP nanoparticles successfully mimic natural polyP's function.
  • Topical application of these synthetic forms can remedy energy deficiency in wound healing.
  • Initial patient studies demonstrated successful outcomes in treating chronic wounds.
  • PolyP-stabilized amorphous calcium carbonate particles showed promise as a soluble calcium source.

Conclusions:

  • Synthetic polyP and its nanoparticle formulations offer a viable strategy to enhance energy supply for wound healing.
  • These novel approaches present a promising alternative for managing chronic wounds unresponsive to conventional treatments.
  • PolyP-stabilized calcium carbonate particles represent a new avenue for therapeutic polyP delivery.