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Related Experiment Video

Updated: Feb 26, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Eosinophilic Ascites: An Underrecognized Entity in Peritoneal Disorders.

Rishi Chowdhary1, Zainab Awan2, Param Darpan Sheth3

  • 1Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. rxc822@case.edu.

Digestive Diseases and Sciences
|February 24, 2026
PubMed
Summary

Eosinophilic ascites (EA) is a rare condition often misdiagnosed. Prompt corticosteroid treatment is effective, but more research is needed for diagnostics and relapses.

Keywords:
Ascitic fluid eosinophiliaCorticosteroid therapyEosinophilic ascitesEosinophilic gastroenteritis

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Area of Science:

  • Gastroenterology and Immunology

Background:

  • Eosinophilic ascites (EA) is a rare condition characterized by eosinophil-rich peritoneal fluid, often misdiagnosed.
  • It is frequently associated with eosinophilic gastroenteritis (EGE) and presents in adults aged 30-50.

Purpose of the Study:

  • This review consolidates current knowledge on eosinophilic ascites.
  • It focuses on etiology, pathophysiology, diagnostic challenges, and treatment strategies, identifying knowledge gaps.

Main Methods:

  • A narrative review of studies from 2000-2025 was conducted using PubMed, SpringerLink, and Web of Science.
  • Included studies required histopathologically confirmed EA with ascitic eosinophilia >10%, imaging, and treatment outcomes.

Main Results:

  • EA pathogenesis involves IL-5-driven eosinophilic infiltration of the gastrointestinal serosa.
  • Diagnostic features include exudative ascites with eosinophilic predominance, peripheral eosinophilia, and bowel wall thickening on CT.
  • Corticosteroids achieve remission in 80% of patients within two weeks.

Conclusions:

  • Heightened clinical suspicion is crucial for diagnosing eosinophilic ascites.
  • Future research should focus on non-invasive diagnostics, comparing biologics with steroids, and exploring genetic factors in refractory cases.