Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Feedback Loops01:01

Feedback Loops

66.0K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
66.0K
Feedback Inhibition00:46

Feedback Inhibition

57.7K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.7K
Protecting Self-Esteem01:27

Protecting Self-Esteem

246
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
246
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

12.0K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
12.0K
Stereotype Threat and Self-fulfilling Prophecies02:09

Stereotype Threat and Self-fulfilling Prophecies

42.8K
When we hold a stereotype about a person, we have expectations that he or she will fulfill that stereotype. A self-fulfilling prophecy is an expectation held by a person that alters his or her behavior in a way that tends to make it true. When we hold stereotypes about a person, we tend to treat the person according to our expectations. This treatment can influence the person to act according to our stereotypic expectations, thus confirming our stereotypic beliefs. Research by Rosenthal and...
42.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI, peer review and the human activity of science.

Nature·2025
Same author

How should the advancement of large language models affect the practice of science?

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Rationalizing risk aversion in science: Why incentives to work hard clash with incentives to take risks.

PLoS biology·2024
Same author

Feelings and flirtations foster long-term cooperation.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Human behavior and disease dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

How publishers can fight misinformation in and about science and medicine.

Nature medicine·2023

Related Experiment Video

Updated: Feb 26, 2026

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
16:23

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Published on: February 26, 2014

15.0K

Screening, sorting, and the feedback cycles that imperil peer review.

Carl T Bergstrom1, Kevin Gross2

  • 1Department of Biology, University of Washington, Seattle, Washington, United States of America.

Plos Biology
|February 24, 2026
PubMed
Summary

The peer review system faces a crisis due to reviewer shortages, impacting scientific quality. Mathematical models reveal a feedback loop where increased submissions and competition for reviewers degrade review accuracy, threatening scientific publishing.

More Related Videos

Pooled CRISPR-Based Genetic Screens in Mammalian Cells
09:05

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

23.4K
Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques
07:52

Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques

Published on: December 1, 2023

1.6K

Related Experiment Videos

Last Updated: Feb 26, 2026

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
16:23

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Published on: February 26, 2014

15.0K
Pooled CRISPR-Based Genetic Screens in Mammalian Cells
09:05

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

23.4K
Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques
07:52

Author Spotlight: Enhancing Cryo-Electron Microscopy by Automated Data Collection and Analysis Techniques

Published on: December 1, 2023

1.6K

Area of Science:

  • Bibliometrics
  • Scientific Publishing
  • Peer Review

Background:

  • Scholarly journals depend on peer review to validate scientific research.
  • Identifying qualified peer reviewers is increasingly difficult, potentially jeopardizing the peer review system.

Purpose of the Study:

  • To develop mathematical models analyzing author, reviewer, and reader incentives in scientific quality assessment.
  • To identify key factors contributing to the current peer review challenges and propose solutions.

Main Methods:

  • Mathematical modeling to simulate interactions between authors, reviewers, and journals.
  • Analysis of incentive structures within the scholarly publishing ecosystem.

Main Results:

  • Peer review indirectly reflects author confidence in manuscript quality through journal selection.
  • The lack of traditional market mechanisms (e.g., wages) for reviewer labor exacerbates reviewer shortages.
  • A detrimental feedback loop exists: increased submissions lead to reviewer overtaxing, reduced review accuracy, and further submission increases.

Conclusions:

  • The current peer review system is threatened by a cycle of declining review quality, driven by publication pressures and journal competition.
  • Interventions are needed to address reviewer recruitment and retention to sustain the integrity of scientific publishing.