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Related Concept Videos

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Related Experiment Video

Updated: Feb 26, 2026

Transcranial Direct Current Stimulation tDCS for Memory Enhancement
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Enhancing memory control in subthreshold depression: a tDCS study targeting right dorsal lateral prefrontal cortex.

Yu-Xiang Guo1, Zi-Li Wang1, Teresa Boemo2

  • 1Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan 430079, China; Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan 430079, China; School of psychology, Central China Normal University, Wuhan 430079, China.

Psychiatry Research. Neuroimaging
|February 24, 2026
PubMed
Summary

Anodal transcranial direct current stimulation (tDCS) improved memory suppression in individuals with subthreshold depression. This non-invasive brain stimulation technique shows promise for addressing memory deficits in depression.

Keywords:
Brain stimulationDepressionDorsal lateral prefrontal cortexMemory suppressionThink/No-Think

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Depression is linked to memory suppression deficits and abnormal prefrontal cortex activity.
  • The right dorsal lateral prefrontal cortex (rDLPFC) is critical for memory control.
  • Subthreshold depression may involve impaired memory suppression mechanisms.

Purpose of the Study:

  • To investigate if stimulating the rDLPFC using anodal transcranial direct current stimulation (tDCS) can enhance memory suppression in individuals with subthreshold depression.
  • To assess the impact of tDCS on memory performance within a Think/No-Think task paradigm.

Main Methods:

  • Fifty individuals with subthreshold depression participated in a single session of either active or sham tDCS.
  • Participants completed the Think/No-Think task, involving retrieval or suppression of neutral and negative stimuli.
  • Memory accuracy was measured under different conditions (Think, No-Think, baseline).

Main Results:

  • A significant interaction between group, stimulus valence, and memory instruction was observed.
  • Active tDCS led to successful memory suppression (lower accuracy in No-Think vs. baseline) for both neutral and negative stimuli.
  • The sham tDCS group did not show a significant suppression effect.
  • A trend for a smaller suppression effect for negative compared to neutral stimuli was noted in the active tDCS group.

Conclusions:

  • Transcranial direct current stimulation (tDCS) shows potential to enhance memory suppression in individuals experiencing subthreshold depression.
  • Non-invasive brain stimulation may offer a therapeutic avenue for memory suppression deficits associated with depression.
  • Further research is warranted to explore the clinical utility of tDCS for depressive symptoms affecting memory.